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How genetically dissimilar does a couple have to be to no longer risk producing children with genetic disorders due to inbreeding? Is it okay to have children with a 4th cousin? 3rd cousin? 2nd cousin? And similarly, does genetic dissimilarity at some point stop being beneficial for couples?

This study found that 3rd and 4th cousin couples have higher fertility rates than the average, and suggest that this is the sweet spot between inbreeding depression and genetic incompatibility due to a condition called 'Rh incompatibility'. What do you guys think?

https://science.sciencemag.org/content/319/5864/813
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>>12578806
Wen ur """tree""" is a diamond rofl
>>
>>12578806
Depends on what your risk threshold is.
Everybody has a number of recessive mutations in their genome which could cause disease if they were homozygous.
The thing is, the chance of two genetically distant people having a (disabling) mutation in the same gene is very small.
The reason inbreeding causes problems is because people who are closely related are likely to carry the same recessive alleles.
This means that two closely related people are much more likely to give birth to offspring which carries two copies of the malfunctioning gene, thereby causing the child to be diseased.
You could calculate the risk by calculating the probability that a child will inherit two copies of a bad gene.
You could probably do this by considering a non-related male and female who breed to begin a family.
Then, imagine the children of these parents breed with each other, and also imagine the children breed with more unrelated people. Then imagine the children of the non-incestuous group breed with their cousins, etc.
If you take into account the number of chromosomes, and you understand inheritance, the chance of a child being born homozygous for a bad gene in each generation should be calculable (albeit a pain)



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