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I think it’s just anxiety, have been under a lot of stress lately but I just want to be sure but could a hard heart beat (over 24 hours so far) be caused by my injections? Ftr I’ve been on hormones for over 7 years but stopped for a while and started again on Sunday.

why did the last one die so quick?

anyway, i've been taking 30mg pio a day for the last month and it might be my imagination but i think my butt getting bigger, my belly still same size tho. Is it safe to add metformin at like 1 pill of 1000mg xtended release a day? should i just stick with the pio for now

I'm injecting every 10 days with otokonoko EC, is it okay to inject in the same thigh or is it crucial I alternate legs

I found this Russian brand of oral estradiol that comes with progesterone called Angeliq, is this a good idea for someone just starting out or should progesterone be added later?

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i just started bica, but i ran out of spiro.

so that means i'm stuck with testosterone very slowly masculinizing me until bica fully kicks in after a week/month/whenever, no?

>>32789687
its crazy, because I am only taking 7.5mg/day for the past 2 weeks (started low because I have a family history of heart disease and wanted to play it safe and titrate up) and plan to go up to 15mg next week and I notice my cheeks on my face finally filled in. I don't know if its a coincidence, but my cheeks always looked a bit sunken in before. Hoping my butt/hips grow more once I up my dose. Was also hoping my belly fat goes down as well though. I heard it to take this no more than 2 months on and a couple months off, so will see how I look at the end of month 2.

I am no expert though, but I think prob just stick with the pio for now and let it do its thing for a couple cycles. I plan to do this on my end.

can i ask about side effects of cypro?
its been one week now (in combo with estradiol patch) and i feel rather fatigued, and about 30-1 hour after i start to feel a bit tingly. it feels like im without drive as well if that makes any sense (i also stopped getting erections almost immediately. i know part of its probably placebo but holy crap my sex drive just stopped)

>>32790604
thank you! I did 2 weeks of 15mg pio daily , then upped to 30mg a day, I plan on taking 30mg a day for 3 months, then i'll take a break just to see.

>>32789170
Been on injections from otk for awhile however my most recent order idk if it's just in my head but it feels like I'm remasculinizing/ not getting the same effects as the last batch. Anyone else experience this ?
Very possible it's all in my head though

>>32791314
You taking your B12 supplements (monster energy) like the OP says? Not that I'm some expert but I'm starting cypro next month and plan to supplement tons of B12.

>>32792458
does b12 drop that quickly though? i know normal reserves last a few years, a week seems quiet fast to deplete that, but i might start. i take other supps for other reasons so might add b12

>>32790465
what is your estrogen method/dose? you'll be fine desu. take 50mg a day and you'll feel it in a week and be like 90% ramped up. you aren't gonna remasc

my boobs aren't growing. am I just fucked because I didn't stay on a low dose of estrogen and use bica? I plan to get an orchi sometime in the next year; has anyone had better results or more breast growth after this?

>>32794361
>I didn't stay on a low dose of estrogen and use bica?
is these actual evidence that low e and bica leads to better breast growth?

what brand of progesterone are you buying and where are you buying it?

>>32794434
i did this and have no boobs. like everything else in transitioning, it's all a crapshoot.

>>32794564
how long have you been on HRT?

I'm really worried my boobs are just done growing now but I've been on HRT less than a year

>>32794671
3 years lol. i have thought about restarting with low dose e + bica again to trying and kickstart growth after the stall. we'll see after progesterone maybe.

>>32794361
how big are your mum's boobs and any other close female relatives?
what is your bmi now, and what was it at the start of your transition?

>>32789687
>>32790604
We need really fully documented logs like we used to have back in the day on forum websites. That part of internet culture seems to be gone forever. But I think pio may be the next stepping stone in MTF hrt if it all pans out. You two need to keep updated

>>32791314
The sex drive will decrease pretty rapidly. Like within a week. They used to give this stuff to sex offenders and would’ve rather does (says a lot about cis men and gender dysphoria too). It’s my favorite blocker to use initially.

>>32794683
did growth stop after increasing your doses? this seems to be what happened with me, I only have breast buds and it sucks. I read something in these threads about gonadotropins a while ago which is what makes me suspect low dose could be good and it's also a rumor I've heard

>>32794701
my mom is 36C, I was like 17.6 and now I'm 19.6

I want to think this just takes time but then I hear people complain of soreness and pain and I never had that at all

>>32794730
Died*

>>32794730
>It’s my favourite blocker to use initially.
why initially? then what after it if not an orchi?

>>32789687
>>32790604
any breast changes (positive or negative) that you've noticed?

>>32794734
hmm ok. what dose did you start on?

>>32794750
I use injections so I don’t need them after a while

>>32794750
>>32794824
Also I’m dumb and detrasition like every 6 months

>>32794835
>Also I’m dumb and detrasition like every 6 months
????? see a psychologist or smth

>>32794814
I titrated up from 2 mg oral estradiol + 50 mg spiro to 8 mg oral estradiol and 300 mg spiro (split 12 hours apart)

my doctor actually increased my dose to 10 mg estradiol but I've still been doing the 8 and recently tried taking an extra 2 mg sublingually to try to spike my levels because I read something on wikipedia about gonadotropins increasing when estradiol reaches some range but I haven't done this for very long and can't say for sure if it has any effect

I'm planning on using 4mg/day estrogen gel on my balls n shaft.

is this enough for monotherapy?

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>>32789170
which is the best one????????SOMANY

Would using transdermal gel 2mg estradiol hemihydrate daily be a good dose for me as a hrt femboy?
I'm not sure if I should do monotherapy or add antiandrogens. I also want to avoid getting tits if possible.

>>32795346
>I'm not sure if I should do monotherapy or add antiandrogens. I also want to avoid getting tits if possible.
then high dose injection monotherapy
gonadotropins are the reason why trannies have such small tits (besides bigger chest)

see fig. 2.
https://sci-hub.se/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.1982.tb00728.x
>In the girls with gonadal dysgenesis (Group A), who had elevated levels of gonadotrophins, the institution of oestrogen substitution therapy instigated normal breast development, corresponding to mid-puberty (P3) after only 6 months of treatment, and with completion of development (Ps) in a considerable proportion after 3 years of treatment. In contrast the girls of Groups B and C, all of whom were deficient in gonadotrophins, showed only the development of breast buds (Pz) after 6 months of treatment and in none did breast development exceed stage P3 after 3 years of oestrogen substitution therapy. Similar results were noted by Burns et al. (1981) in girls with hypopituitarism due to craniopharyngioma.

and also stay skinny of course, estrogen lowers appetite, so it will be easy

>>32795383
nta but I really wonder if this is time sensitive or if proper growth can happen years later

I also worry about stunting my growth, like "fusing" my breasts like bones fuse but I have no idea if either of these concerns are warranted and I don't know if anyone does

but a FtMtF friend of mine said hers grew a bit at 25 after stopping T, relative to how they were before T, so who knows?

>>32789170
anyone in aus able to sell me some estrogen? particularly nsw

>>32795383
>https://sci-hub.se/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.1982.tb00728.x
wait so what if i want big tiddies?

>>32795403
>nta but I really wonder if this is time sensitive or if proper growth can happen years later
but they were monitored for years, fig. 2. and 3. are 6-7 years after HRT and you see their nonexistent development. that's a lot of time.

>but a FtMtF friend of mine said hers grew a bit at 25 after stopping T, relative to how they were before T, so who knows?
maybe she just got fatter than previously

>>32795426
bicalutamide + a tiny dose of estrogen to make bicalutamide's work to suppress T easier.

>>32795430
I mean that I wonder if you can get proper growth by fixing your hormone levels later or if having high estradiol with low gonadotropins fucks you somehow

>>32795407
I dont need much just enough to tide me over while I wait for my shipment

what are negative side effects people usually get while taking piog?

>>32795898
edema (which can accelerate heart failure in those at risk), appetite increase and weight gain (desirable for fatmaxxers, weight gain is in lower body, pioglitazone prevents even subcutaneous belly fat gain, and the weight gain is ~4 kg in half a year if you simply continue your previous lifestyle), osteoporosis ("Pioglitazone inhibits bone formation and does not seem to affect bone resorption. Postmenopausal female patients rather than premenopausal or male patients are particularly vulnerable to this side effect of pioglitazone", when used too long but it's reversible). bladder cancer is a risk of diabetes itself and 2017 meta-analysis found pioglitazone didn't affect the risk. hypoglycemia is a risk when you take it together with insulin or sulfonylureas, not in monotherapy.

>>32795974
thx :)

hypothetically, what would happen if u took pio w/o estrogen? i'm not even planning to but i just wanna understand it

>>32796444
selective increase in lower body fat and improvement in insulin sensitivity, weaker than on estrogen, one study said 15 mg in women was equivalent to 30 mg in men

>>32796487
wait so it would give them a timmy thick bod??

>>32795974
>bladder cancer is a risk of diabetes itself and 2017 meta-analysis found pioglitazone didn't affect the risk
wait really? can you post this? i've been avoiding it because a couple of my ancestors had bladder cancer and i read a (i think it was a review rather than a metaanalysis) saying it did probably did increase the risk

whats pio

>>32797141
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544610/
>People with type 2 diabetes are at increased risk of bladder cancer. Pioglitazone is said to increase it further, although published evidence is mixed. We conducted a meta-analysis to determine if any link between the use of pioglitazone and an increased risk of bladder cancer can be found. A comprehensive literature search was conducted through electronic databases as well as registries for data of clinical trials to identify studies that investigate the effect of pioglitazone on bladder cancer in diabetic patients. We used the risk ratio (RR) and the hazard ratio (HR) provided by the studies to illustrate the risk of occurrence of bladder cancer in the experimental group compared to that in the control group. Fourteen studies using RR and 12 studies using HR were included in the analysis. The overall RR was 1.13 with 95% CI (0.96–1.33) with low heterogeneity among the studies using RR, suggesting that no connection exists between use of pioglitazone and the risk of bladder malignancy. The summary HR was 1.07 (0.96–1.18) allowing us to affirm that there is no link between long-term use of pioglitazone and bladder cancer. Our results support the hypothesis of no difference in the incidence of bladder cancer among the pioglitazone group and the nonuser group. Our conclusion is that the explanation of hypothetically increased risk of bladder malignancy should be attributed to other factors.

>Azoulay et al. stated that participants prescribed thiazolidinediones (pioglitazone and rosiglitazone) were more likely to be obese, to have ever smoked, and to have uncontrolled diabetes than those who never used any thiazolidinedione, this way setting significant baseline differences among the groups and making it harder to draw a definite conclusion about the connection between pioglitazone and bladder cancer.
>Common metabolic complications associated with diabetes mellitus such as higher body mass index (BMI), obesity, and insulin resistance are also known to be individually connected with an increase in the risk of bladder cancer development in diabetes patients [54–56]. The recommendation to apply pioglitazone as a third-line therapy for type 2 diabetes leads to it being prescribed to patients with more advanced forms of the disease with higher possibility of metabolic and other complications which could be another confounding factor for increased bladder cancer risk.

Gave myself an injection yesterday and now I have a painful lump where I poked myself.
This shit is a fucking scam, none of it works and I should just fucking kill myself when this is the fucking result I get for trying to do something.

>>32797231
isn't that normal for intramuscular or subcutaneous injections? just pop an advil

>>32797270
>give yourself painful lumps all over the body, you'll become a woman that way swear for realsies I'm not crossing my fingers behind my back nuh-uh

>>32797284
lol you can always try oral or patches or gel if it's that bad for you

>>32797298
>just try this one thing and then another and then another and then another and then another, ofc there's a solution for you, you're not wasting your time, nuh-uh

>>32797306
which part of the body did you inject and was it into the muscle or fat? some areas of the body have more muscle than fat and some have more fat than muscle

>>32797324
front thigh. I tried to do subq, I tried to pinch my skin but since I'm fat as fuck I can't really do that. So I dunno where the fuck I poked myself, probably not in the muscle, might've even injected into skin, although I don't know how thick my skin is.

>>32797342
intramuscular is better for front of thigh
https://www.youtube.com/watch?v=e0wDPZ0D9Wk

>>32797217
wonderful thank you so much

>>32797366
I inject estrogen.

>>32797231
1.5 inch needle into the glute i've been doing this for 4 years with 0 issue.

>>32797366
I guess I'll switch to injecting in the abdomen.

>>32797416
it's the same thing, just different compound, lol

im finally going to get on hormones very soon, not DIY
i'll be going to a highly recommended provider that listens and honestly i only know barebones stuff.
can someone explain what i should ask for to prevent hondose, both in terms of the type of E and AA and the dosage?
i know i want to take some form of sublingual E and bica or cypro but i dont know whats best for me nor do i know exactly what kind of HRT they can prescribe.
so... what do i ask for? i want to avoid hondose and perma conetits

Danish friend has asked me for help acquiring injectable HRT, any resources or pointers?

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>>32797763
you need >200pg/ml estrogen and <10ng/dl testosterone
50mg is good daily dose for bica and 12.5mg for cypro
you need multiple doses in a day if you're taking sublingual

>>32797930
>you need multiple doses in a day if you're taking sublingual
*since it tends to give unstable blood levels

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I have been getting a few spots on my face recently, I am very worried... Could this mean something has fucked up???

My dose is 6mg EEn weekly, along with 12.5mg cypro every two days, and my most recent blood test (4 months ago, overall 10 months into HRT)

>Testosterone - 15 ng/dl
>Estrogen - 75 pg/ml

though I had two blood tests before this, and my E was at 100 pg/ml on both, I have also upped my dose by 1mg since then.

>>32797930
>>32797952
so about what kind of dosage and of what type of estradiol? i know people say to stay away from certain types

>>32798107
also NTA but whats a good oral estradiol to use sublingually? otkp's doesnt seem to absorb that way

>>32797930
don't take both bica and cypro

50mg bica and 4mg sublingual E is a good starting dose. then swap to injections in 3-6 months. can probably drop the bica to 50mg every 4 days at that point or 0

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my trough levels on spiro and injectables for 6 months are are T: 3ng/dL and E: 179 pg/mL, what e levels are safe to switch to monotherapy?

>>32798024
wtf how is your estrogen so low on injections?

worried that my levels are fucked because i cant even afford anti androgens

>>32798372
>don't take both bica and cypro
didnt say that, just phrased awkwardly

>>32798107
2mg tablets
as many throughout the day as you need

is it possible i have a milk tumor if when i squeeze my boob a tiny amount of milk comes out? im on a large dose of injections because i cant afford blood tests.

pls help i am worried

>>32798877
dose?

>>32798906
10mg/10days een, im really afraid to lower my dose because i cant afford bica and spiro was awful for my health and im afraid of prolactinoma from cypro because im pretty sure my prolactin is already high, but i cant even get it tested because im a broke neet boymoder living in florida.

>>32798877
prob get ur prolactin checked
if u take CPA that can raise ur prolactin to really high levels

>>32798931
i cant afford it ;(

even looking for non-passing timelines, people almost always change more over a year and a half than i have even if it’s subtle. even with skincare added my skin doesn’t even really look any different

i got deformed looking flat breasts and very very slightly slowed down body hair growth. and my dick still works when i want it to not, so that’s awesome

i’m 99% sure i unironically have an estrogen receptor deficiency

1.5 years hrt and bica; 4 months on injections

>>32798931

whoops i didn't refresh and didn't realize u already addressed this my bad >>32798922

>>32797231
sounds like you either injected too close to the surface and/or had an allergic reaction to the carrier oil. i've been doing injections for about a year and have never had any lumps.

>>32798922
very high doses of estrogen can cause hyperprolactinemia (and it's not associated with prolactinoma, prolactinoma is due to progesterone receptor). statistically your dose is fine, but maybe you have metabolism like me and your levels are high as fuck. anyway for blood clot risk it would be simply like being on oral estrogen.

>>32798940
what are your levels?

>>32799284
my e was like 200 a week after injecting and my t was <15

>>32798803
I have no idea, im scared

>>32798820
np just clarifying for them

is it even worth trying to start for me
i'm decently attractive, quite tall, and get plenty of attention from girls, but i've felt like i wanted to transition since i was eleven or twelve

thing is, i never could, since i grew up in a strictly christian household. coming out to them was a death sentence. i moved out recently though (thank fuck).

starting HRT for me would mean giving up looks, attention, a lot of friends, family, i'd be an entirely different person, i'd have a lot of very big problems to fix, but i dont know if i'm happy now, or if i would be even if i went through with this

i turned 21 last week, is this worth the chance, anonettes?

>>32800194
my opinion is yes if you have gender dysphoria

i transitioned at 27 after college and i had a six figure salary, girlfriend, strong social circle, hobbies, attractive and fit.. and none of that fixed that nagging feeling of gender dysphoria

32 now and the happiest i've been in my adult life. still have the career, a girlfriend, looks, friends, hobbies.. it was a lot of work but here i am

>>32800217
at what age did you look the way you wanted to from the HRT?

>>32800424
to be honest? I don't. HRT isn't a miracle. it is a making the best of the situation i am experiencing.

still a work in progress. i've had an orchi. very likely will get FFS in the next 2yrs. outside of HRT there are a ton of factors that have made me feel/look better. diet, skincare, haircare, fashion, etc

HRT is just one piece of a transition

>finally manage to get pio after spending forever trying
>lost in the mail
i want to die

>>32800475
sounds like a blessing, taking pio is very dumb. it doesn't do anything you can't do without pio, and comes with added side effects

>>32800491
cope

>>32800653
what does cope mean in this context? i got fat distribution without pio because that is how hrt, diet and exercise works.

>>32800679
pioglitazone is faster and stronger than diet and exercise

Is there any reason to start with a lower dose of progesterone? My breasts haven't grown anymore for the last year, should I just go with 200 mg up my butt daily right away?

Is starting cypro at 12.5mg ok?

>>32789170
If I start 50mg bica and 1.25mg fin daily, how bad of a conetits case am I going to get?

>>32794861
>too much pride
>not enough time.
I work full time too in a stressful field. The weekends are reserved to downtime and catching up with the rest of the world. how does a visit usually go?

>>32800679
and genetics. You may just be lucky

>>32800802
That's what I did. Um, I think it worked out kinda well? I dunno. It doesn't really do a ton on it's own, but I do not regret my decision and overall it's effects were only positive, except for a weird reaction I had when I first went on it where the skin on the back of my hands was super dried out, but it was a pretty minor issue and went away on it's own after only a few days.

>>32798940
in this one study w/ERa insensitivity the solution was high dose e, but that was due to the specific variant of ESR1 mutation
>https://www.nejm.org/doi/full/10.1056/NEJMoa1303611

>>32799052
I fucked up and contaminated the vial when I got it. Now I get to suffer the consequences

>>32800802
I see alot of people at 25mg so I’m unsure

Been on HRT for 1.5 years, and I've noticed no changes besides growing (pretty small) tits. I started at 17 which I thought would be early enough to at least do *something*, but I guess not. Did I do something wrong, or did my genetics doom me and it's been over from the start?

>>32800863
nope i just put in consistent work

>>32800961
I also had nothing but breast growth when my E dose was good but my T wasn't suppressed enough, maybe get your levels checked or raise your dose(s)

>>32800802
yea that dose is fine to start with, cypro kinda sucks tho, bica is way better at least ime.
cypro killed my sex drive and made me a bit depresso. bica or monotherapy are both awesome in comparison.

>>32800916
above that 10-12.5mg range is where more risk begins if you take it daily, and begins to enter pointless overdosing range as 12.5mg is adequate
if u do 25mg every few days that's fine but i'd imagine the bigger spike in your system of cypro may lead to more risk for the brain/prolactin issues

>>32800982
>denying that genes matter
you sound kinda dumb rn btw
consistent work does matter too ofc, but implying genes don't matter at all is super ignorant

>>32801007
almost every trans woman (even including me) has diet and exercise they could put in that will trump genetics

>>32801007
Ok thanks

>>32800991
My T is a bit high, I've been hesitant to raise my aa dose though since I've had odd side effects when I previously tried a higher dose. I might as well give it another shot though.

I wonder if it's too late now seeing that I've wasted the past year and a half.

>>32801117
>I wonder if it's too late now seeing that I've wasted the past year and a half.
Depends on your particular situation and goals, but people have even become passing way after puberty

Would it do any harm if I start with injecting estradiol valerate instead of pills? I know that pills are good for breast development somehow, but let's ignore minmaxing for a moment. Is there a higher chance of me fucking up my health by injecting versus pills?

>>32802143
>Is there a higher chance of me fucking up my health by injecting versus pills?
Assuming you do everything correctly, injecting is less unhealthy since it doesn't involve your liver and unlike oral it doesn't increase the risk of blood clots

>>32798024
BUMP

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Is there any difference between the non-hydrochloride 84449-90-1 and hydrochloride 82640-04-8 variants of raloxifene? I'm planning on making a gel.

>>32802502
... how the f*ck

>>32802559
;-; i cannot run labs currently, but god im really scared, like yeah sure cis women get acne, but isnt E supposed to like... like isnt getting acne a big sign of T rising? i really really don't want to masculinize im really scared

>>32802597
i just want to know if i *should* be worried or if im being delusional again, like if my everything is good and im just being irrational y'knwow?

>>32802580
Acne depends on many factors. As humans, we tend to jump to conclusions, especially if our mind is fixated on a particular outcome. Therefore without lab results, the connection with the testosterone in your system and the appearance of acne can only be concluded to be superficial. The best thing to do then is to don't worry about it and wait until you can get labs again.

>>32802678
I see, so everything is ok right? like if you look at my previous blood tests, im doing alright hrt-wise right? like if I kept on the same dose and everything, then surely im fine right?!"?

>>32802701
Your T suppression is good, though your E is oddly low for the amount you are injecting. Regardless, it should be fine as long as your T is suppressed, which it is. Actually I just now noticed that you are using cypro alongside it. Why are you using an AA when you are already using high dose E injections? The E should be able to suppress T by itself.

>>32802770
Well it's cause E only suppresses it if it's at a certain level, which... it isnt right? ugh im scared of being hondosed.

Heyy, 7.5mg pio anon here!
>>32794717
Yep, I will do my best to give updates every now and then. I plan to up my dose to 15mg in a couple days. hopefully will have some data to share by the end of next week or the week after.
>>32794809
Ive read that there is a negative effect, but so far I haven’t experienced anything bad? I been on hrt for a year now and they are pretty much tanner3 conical, but they are now rounding up as of recent. Not sure if its the pio though since I also take 100mg prog nightly as well. Will continue to update here as well.

>>32802795
That is true. The only thing to do then is continue monitoring your levels then.

>>32802871
but you're 100% sure im good right? like not masculiizing and im femizing and my levels are good and there is no reason to believe they raised right? like im good

>>32802882
There is no absolute certainty, but yes you are most likely fine.

>>32802894
i'm not talking about absolute certainty, but like, I have no rational reason to think that i'm masculiizng is what i meant right

>>32800844
initial visit you lay out whats wrong / frame your context
sequential visits depend on the type of therapy being employed.

>>32804090
also pride is usually not actually pride but stubborn reserves. your not proud of who you are and you already engage in some form of help anyway since youre in this thread.
at the very least your in the contemplation stage of seeking out psychotherapy, you just need to convince yourself to start

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Has anyone here tried Domperidone for breast growth. My growth has stagnated after about 2 years of E (and 1 year of prof), so I was considering trying Domp to see if I can’t get any more breast growth.

>>32805267
it is temporary growth but it does increase volume for most people while on it

>>32798940
same here. really no clue what the issue is and it seems like there's really no way to tell. people talk about estrogen sensitivity levels and receptor deficiencies but there's no way to gauge that as far as I know.

>>32806478
what are your E, T and DHT levels. regimen?

>>32806478
>estrogen sensitivity levels and receptor deficiencies but there's no way to gauge that as far as I know.
there is a simple one, just listen to the facts and not insane r/drwillpowers' theories.
you couldn't suppress gonadal testosterone levels. additionally, you would still grow after reaching adulthood as estrogen is the hormone necessary for growth plate fusion and testosterone on its own won't do shit.

https://www.sciencedirect.com/science/article/pii/S2211124723004011

Can a smart person help me understand this paper?

>>32806478
>people talk about estrogen sensitivity levels and receptor deficiencies but there's no way to gauge that as far as I know.
ok, I will tell you one that if you use your brain will prove you that it's something you shouldn't be concerned except for some rare genetic issues that 99% of that 0.2% trans minority won't even face
Test SHBG, SHBG is going to get produced when estradiol attaches to estrogen receptors in your liver, more E at more ER means more SHBG, if it stands (and it does, even for these freaks at reddit coming up with these theories, in fact they obsess with SHBG for some weird reasons) then it means your receptors work just as they should (at least in the liver, but no reason to assume it's different elsewhere)

>>32808249
doesn't matter that much for humans as humans aren't mice, our endocrine system is much different, but I think they say that E2 treatment should b required to stimulate fat cells multiplication, that happens in trans women already and it's easily observable with time and proper diet and ofc HRT

>>32794361
>my boobs aren't growing. am I just fucked because I didn't stay on a low dose of estrogen and use bica?
no, fix your levels, look for other issues like bad diet, lifestyle, etc. many things can block it, if you unblock it they can grow

>>32797231
>>32797270
>isn't that normal for intramuscular or subcutaneous injections?
no? or at least not for I.M., I do gluteus maximus injections for years and it's almost never painful unless the specific part of body was abused heavily by too frequent injections into simialr area without letting my body repair the damages
if you feel pain then change spot by 1 cm, but still in safe area, clearly you hit something that you didn't mean to
idk why you'd have a lump, maybe because of subq injections? in i.m. I don't have a lump and I inject 1 ml of oil around every week

i woke up and my buds are gone?
they were completely hard and painful for two months and now its just nothing

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thinking now, what kinds of estradiol can be taken sublingually? EEn is injection and EE is apparent shit for you. EV or EH is supposedly what you need to take? also can someone explain the difference between Estradiol Hemihydrate and just Estradiol in picrel?

>>32810371
a hemihydrate is a substance that contains 2 molecules of a certain compound for every water molecule, usually in a crystal form if solid
estradiol hemihydrate contains 2 estradiol molecules for every molecule of water

is it tru raloxifene wont shrink/stop boob growth? Even with low dose E

>>32809154
if research done on mice isn't usable because they're so different, why do we do research on mice?

>>32806674
332.4 pg/mL e2 (433.5 pg/mL after recent test, fucked up due to multi vitamin)
175.7 pg/mL e1 (255 pg/mL, same as above)
147.2 pg/mL dht

3 years hrt, was on 3.6 mL every 5 days, dropped to 3 mL after recent test but gonna get tested again after not taking multi vitamins since I think that fucked my most recent results.

>>32809131
118 nmol/L shbg

>>32810841
because it is better than nothing

>>32810846
T levels? your DHT is a bit elevated. just monotherapy no prog or anything?

>>32810984
sounds like bullshit answer desu

>>32811029
well it is the truth. human trials have limitations of use due to ethics (which is good)

>>32811000
31 ng/dL (again the multi vitamin error test, same dosage as prior where I had 23 ng/dL). just monotherapy, no prog, no aa.

>>32810452
Where did you hear that from?

What happens if I put my estradiol pills in my butt?

>>32808249
Use chatGPT to summarize it

>>32810841
It's a great jumping off point and we are similar in quite a few ways but there are differences. Like, for example in breast research mouse breasts are composed mainly of fat, with lobules strewn in that fat, but human breasts are mainly stroma+fat with lobules surrounded by stroma; which leads to certain differences, but a lot of similarities between say ERaKO for humans or mice for the overall consequences of ERaKO (or say, ESR1/ERa insensitivity for human cases where it happens due to a mutation).
So it's good for creating theories, but those need to confirmed for humans due to said differences.
So, for example, you can definitely read that paper and then find parallels in human research; as likely there is overlap.
Sadly, people like >>32809154 use it an excuse to not even read said papers while just being lazy then discarding any parallels, or at least that's how they tend to be in the transfem hrt community.

>>32812625
>but a lot of similarities between say ERaKO for humans or mice for the overall consequences of ERaKO (or say, ESR1/ERa insensitivity for human cases where it happens due to a mutation).
but a lot of similarities between say ERaKO for humans or mice are the same for the overall consequences of ERaKO (...)
little fix on wording

If I think my breast growth has stalled 8 months in what bloods should I get tested?

>>32789170
I won’t be able to take my cypro and estrogen for a week will anything bad happen, I’ve been on it for like a month and a half now

>>32812625
the amount of research on mice that doesn't translate to humans is staggering though?

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so, i need to take .66 mg of sublingual EV 3 times a day to get 2 mg, right? how do people do it? the closest i can get to that dose by cutting the pills is .75 mg so i guess i could shave off some of the pill to get it close to .66? tho i suppose some of the medication is lost when you cut up the pills so that .75mg is probably closer to .70mg?

>>32816508
you take a higher dose like 4mg (split 1 pill in half and do 1mg/2mg/1mg) or you take 6mg (2/2/2). there is no reason to start lower than 4mg

and if you absolutely have to do 2mg you can just do it twice a day until you can get more

>>32817184
well the 2/4/6mg progression is what a lot of people recommend so i'd rather go that route desu

>>32789697
you should alternate otherwise you'll develop scar tissue

>>32818661
scar tissue for once every 10 days?

>>32795443
not the other anon but whats considered a tiny dose, my diy is in the mail and i planned on 4mg of transdermal E daily +50mg bica, should i move to 2mg or is that hondosed.

>>32818622
i think only uninformed doctors suggest starting at 2mg. informed people start at 4mg minimum.

>>32818755
just slightly change the spot. i do each glute every 5 days and do just slightly change locations in the safe zone

>>32802855
>Yep, I will do my best to give updates every now and then. I plan to up my dose to 15mg in a couple days. hopefully will have some data to share by the end of next week or the week after.
yessssss

pio will deform your breasts and does nothing that can't be done with hrt, diet and exercise

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>>32819123
do people here think dr powers is a complete quack or something? hey may be eccentric and may have some gamer moments now and then but he seems to know his stuff.

>>32819275
polymorphism?

>>32819406
idk i think he's referring to how some people produce a lot of estrone on oral estrogen and by measuring buccal/SL levels after a month he can detect if this would happen to the patient? lol i really dont know

>>32819275
>one month
that slide is also out of date. you can find it in the comments of a question on his sub he starts people on 4mg now. just another one of his abandoned half cooked theories that he abandoned

Een take some time to build up doesn't it? almost 3 weeks since I switched and I'm worried it's not working ...

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>>32819805
https://transfemscience.org/misc/injectable-e2-simulator/

yeah like 3-4 weeks

>>32819275
he has surely seen a ton of patients, and is open to trying out stuff with them if they request to help them out.
I think he has heart in the right place, sometimes he's wrong, but he's trying and I think we do need people like him.
He's also kinda tall and hot desu and has biggest cats in the world, idk why people hate on the guy desu
he does sometimes say some baseless stuff, but he's trying to make trans healthcare better for us all too, I personally like him and respect him as a doctor. I always find it interesting to read on reddit what he came up with, even if it's not always fully correct informations, but just theories.

>>32819171
>pio will deform your breasts
source?

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>>32819892
this is why you make your first injection much bigger to get you up to target levels quickly

>>32822237
>idk why people hate on the guy desu
>he does sometimes say some baseless stuff
empirical only

we all know starting with prog sabotages your potential, but is it a bad idea for the first step of mtf transition to be orchie?

how long can i be without an e patch for? need to remove hair on stomach

>>32795383
This can't be the only factor, though.

Almost every trans girl has suppressed LH and FSH. Yet not every trans girl has bad breast growth. So it's possible to get good breast growth even with low gonadotrophins.

>>32823415
Correct, it is a dumb theory that doesn't hold in reality. You can go to transbreasttimelines subreddit and see women with all kinds of doses get and not get breast growth

>>32822406
been talked about here a few times. people ignore it because they would rather order a pill online rather than diet and exercise.

>>32823415
>>32823621
I think trying to pin one cause as the reason for poor breast growth in trans women is silly. I think it makes more sense for it to be a multifactorial issue.
What would you give as the reason for the results shown in the >>32795383 study, if gonadotropins weren't at least partially responsible?

>>32823768
cont.
What I mean by my question is, is there some other issue that is present in all the women with reduced gonadotropins that isn't present in the women with normal gonadotropins that is a more likely cause of reduced breast growth?
So are the low gonadotropins and reduced breast growth both caused by a different issue, rather than the first causing the second?

is monotherapy even safe? is pumping yourself full of estradiol without doing any blood tests for side effects safe?

>>32823847
should i continue taking t suppressors with injections?

>>32823847
you asked two different questions. yes hrt is safe. yes you should do labs

>>32823806
trans women aren't teenage cis women. endocrinology is complicated.

>>32823859
depends on your levels. most people can do monotherapy. some need blockers for adrenal DHT or another reason

>>32802370
bump

>>32823883
Yeah exactly my point. We are different in multiple ways and I am interested in what those differences might be.
I would imagine reduced levels of GH/IGF, gonadotropins, and adipose cell proliferation come into it, but I would be interested to know what other factors might be involved.

And my question about that study is, if the gonadotropins aren't a factor, what would explain good breast growth in the normal gonadotropins group and reduced breast growth in the low gonadotropin groups?

>>32822626
>but is it a bad idea for the first step of mtf transition to be orchie
i dont think anyones actually lead with that since you have to be on hrt for a year or whatever.

>>32800491
pio is just so much more effective at fat distribution then simply weight cycling its not even close

>>32823680
I know people who took pio, and have talked to them about their experience; it does not deform boobs, and research does not say as much, it only says it will lower a specific stem cells population (due to being turnedi nto fat cells) and that's it.
Anyways, ppar-y agonism is what you're doing via good diet anyways, lol, just pio hits that receptor with more potency than just say mono-unsurated fats.

Did it mess up your breasts though, is that what you're saying? I'd like to hear about that if so

>>32823847
relatively yes, estradiol is quite safe, even in huge quantities, but it's counterproductive for transition anyway to go that high
monotherapy is likely much safer than some crap like Cyproterone Acetate that can give you a brain tumor and is prescribed like a candy, because docs are afraid of BIOIDENTICAL ESTRADIOL as much as of synthetic outdated estrogens like ethinylestradiol that actually were dangerous
basically use your brain (or go to a doctor to do it for you, a good endo), run tests and it's safe

>>32823415
>This can't be the only factor, though.
It's not, there are surely many factors at play and it's a right balance of it all + age and current body state might make a huge difference, sadly no ready recipe for all at this point yet.
>Almost every trans girl has suppressed LH and FSH.
You'd be suprised with people getting trash doses of E2 pills and a bit of spiro, lol. probably like 50% of people who are too stupid to put their blood result numbers into google, proven over and over by more stupid people posting their results without units, such people take their 2-4 mg E2 pills daily and wonder why they have no changes with 250 ng/dl T and LH >1 xDD

>>32825392
nta but i think the worst it can do is potentially reduce the amount of glandular tissue you grow if you take pio very early on as your breasts are still growing. but if your breasts haven't grown for like a couple of years i really doubt it will do anything to your glandular tissue, and idk maybe it will even add some fat to your boobs??

My FSH is supressed but my LH isn't. I'm on a low dose. Is this to be expected? Is FSH much more sensitive to reduced GnRH than LH?

>>32825806
Nvm I just looked at my pre-hrt blood test and my LH was at the top end of the reference rage while the FSH was at the bottom. So I guess that's just how my body is.

>>32825806
why do you provide so little info
estrogen and testosterone levels? antiandrogen?

>>32825871
E: 565pmol/L
T: 3nmol/L
Via oral monotherapy.
My T is well below the reference range so I'm not worried, I'm just interested that my FSH is basically 0 whereas my LH is within reference.

>>32825969
T is too high. it's within lab reference range, but that range includes PCOShons. the true one allows <50 ng/dL (1.7 nmol/L). increase estrogen dose a little.

>>32825969
>oral monotherapy
most likely your problem

If your testosterone is sufficiently suppressed, how much enanthate should you inject? I’m currently doing 2mg. Mono EEN with 4mg brought me to 360pg/ml so I’m guessing 2mg would get me to about half, right? Which should be good with suppressed T

Completely unfamiliar to any of this and want to start, don't want to grow breasts though I would be okay with small ones. What should I take and how should I go about it?

>nearly 2 years in on e and t blockers as a midshit
>little to no breast growth, still look bricky as fuck and have actually somehow grown taller
>get pilled by schizos on here into taking even more drugs like pio and prog gel
>still nothing, i just have a moderately feminine face on a linebacker body
does anyone here know the easiest combination of meds/booze with to die in your sleep? i'm so fucking done with all this stupid hugboxing shit, i will never pass and i'm tired of people manipulating me. i just want to die on my own terms

>>32826992
how long did you take pioglitazone and how much your weight increased

i know most of you are mtf but does anyone have ftm diy links they can send,specifically for buying in UK?

>bought EEn, but now I can't take it
Fucking hell it's so expensive to bank sperm, I just don't want to deny myself the opportunity of biological children in the future because I'm an only child. Millions of years of evolution to end with a fuck up like me.

>>32827120
>I just don't want to deny myself the opportunity of biological children in the future because I'm an only child
because?
why do you need to breed?

>>32827120
Same. It's the only thing that stops me from starting hrt
Did you find any info on fertility rates of detrans mtf and those who recieved bica monotherapy?

>>32827265
I have always wanted children of my own, adopting just isn't the same. I want to see them grow and flourish, and live a life I never had.
>>32827310
I don't think it's worth the risk, I can't really find any studies on monotherapy fertility rates, but saving sperm is about $3000 for 12 vials stored forever through Legacy. There's a $1000 option but it's only stored for 5 years. Gonna have to postpone a month or two to afford that and then another month or two to collect and ship samples...

>Moreover, troglitazone has been shown to be more effective in reversing insulin resistance and glucose tolerance in models of high sugar and fructose feeding (Lee et al., 1994; Santure et al., 2003) compared with high-fat feeding (Khoursheed et al., 1995).
i wonder what does it mean

Thougths on pueraria mirifica as stand in for hrt? It'll be for the first two or three months, in my country it is really hard to get diy stuff but I would like to start now. Is it gonna do anything at all or will it be the same as not taking anything until my hrt gets approved?

>>32789170
4y hrt stable levels just switched from lenajuice to EEn. orchi in november.
would like to try IM hydroxyprogesterone caproate since it's on the same 14-day cycle and i can never stick with rectal admin. does anyone have experience with this? the (scant) information i've found is that 250mg is way too much, and the orchi means i will need to lower doses anyways, right?

>>32827610
https://pubmed.ncbi.nlm.nih.gov/17185797/
>The present data clearly demonstrate that a long-term treatment of PM at doses 10 and 100 mg/kg BW/d, via oral route, does not alter a male fertility and a hypothalamus- pituitary-testis axis.
>The PM-10 and PM-100 treatments had no effect on testicular weight, sperm number, and serum LH, FSH, and testosterone levels.

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need help in regards to maintaining fertility in mtf hrt

i see conflicting info on this topic, as some sources claim that if you stop hrt for a period of time you'll return to producing sperm normally, meanwhile other sources state that you can end up losing the ability to even have an erection completely

my guess is that it depends on age at start of hrt, as well as the amount of estrogen/anti-androgens you take

any tips for someone who's 19 and hasn't started hrt yet to preserve fertility?

Whats the best app to buy btc? i want to order from lena but need to buy crypto first

>>32828028
Binance has good rates, but if you live in Denmark, or other countries where banks have banned spending money on crypto exchanges, you can use Paxful to buy P2P with PayPal. Although expect a 10-20% markup with that method.

>>32828028
CashApp worked great for me, Coinbase is still holding onto my money because they're cancer. Make sure you're using something like Cake Wallet to protect you and the seller, and always buy more than you think you need because transaction fees add up.

>>32827984
do sperm banking and then stop worrying about it

Dose for these tests were 5mg EEn weekly and 12.5mg cypro every two days, since the most recent blood test I have bumped the EEn dose up by 1mg.

Blood tests
>3 months in, 100 pg/ml E, 10 ng/dl T
>6 months in, 100 pg/ml E, 8 ng/dl T
>10 months in, 75 pg/ml E, 15 ng/dl T

Currently 1 year and 1 month in now, have gotten a few spots on my face and I can't get a blood test for the next good while, could I possibly be masculizing? like could my T levels have raised quite alot or my E

>>32828237
how many times are you going to post this

>>32828349
i just want a conclusive answer

>>32827984
if ur concerned about fertility then ur faketrans sorry not sorry

>>32828362
this is not true, but you should just get over it and accept that you might lose fertility but it's worth it if you have gender dysphoria

>>32828237
you're taking cypro with estrogen so it's enough for T not to rise
DHT might be too high the whole time, and there's really no way to know via blood testing for sure if it isn't elevated, only to confirm. acne suggests DHT is elevated.
maybe you're using a comedogenic sunscreen or something

>>32828478
Is this something to worry about bigly though? I wont be able to get a blood test for about another year. im so scared of masculizing

>>32828502
if you want to be sure, use bicalutamide
btw i noticed something mysterious in studies on contraception
in the first months SHBG massively increases, but later it decreases. it's still very high, more than pre-treatment, but that decrease is puzzling.

>>32828553
Mhm but like should I worry about this seriously?

>>32789170
please convince me endocrinologically that I'm not actually experiencing PMS

is 18 ga needle too big for drawing my injections? i want to make sure i don’t wear out the seal as this bottle should last me a long while. also i have a lower bmi (like 18 fluctuating) and a smol butt, is 1 inch 25 ga needle gonna be okay or will i hit bone if i push it all the way in??

how often should i liver test with Bica? is 3months fine since ill do that for E/T levels or do i need monthly?

>>32828362
idc if i'm faketrans or not, i just want to know how to minimize risk of fertility loss

>>32828967
liver toxicity on bicalutamide shows very fast

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>>32789170
is there any lab blood test online for Alberta Canada at all? i keep getting put in awkward situation where doctors only want to monitor my testosterone levels, not estrogen and such. though its mostly my fault for being scared of communicating that.

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is there any actual danger of taking raloxifene or is it 100% safe? almost everyone i saw taking it said they had no side effects and such. but i heard something concerning that theres no long term study about raloxifene so i am kinda paranoid it'll fuck me very badly in the far future if i take it.

is this the right test or should i add anything before i buy it...plan on getting this before starting HRT and then every 3 months
https://www.ultalabtests.com/test/gender-reassignment

and then this once a month until 3x since ill do bica
https://www.ultalabtests.com/test/lh-1-liver-health

>>32828361
You won't get that on 4chan

>>32828349
Regardless of hormones or potential masculinization, its normal to get a few spots every once in a while. In the worst case scenario it could be a DHT issue, but you wouldn't be able to tell definitively without blood test. If you're that worried about it, you could try switching your cypro out for bica. Alternatively if you're happy with cypro you could add dutasteride on top. You're probably ok unless you start to notice more DHT related symptoms, but those two options (mainly the bica one, to keep you on the least meds necessary) could give you some peace of mind even if there is no problem.

>>32828361
Sorry, but >>32830357 is right, its a free-for-all here though we try our best to give helpful and accurate info

>>32827103
real question but would a gym lockler room (or rather looking for juicers) help you get a plug? the drug exchange is pretty open in Australian gyms

>>32828478
>acne suggests DHT is elevated
not them but i started getting ance after starting e and cypro, could it be indicative of just hormone fluctuations or is definitely high dht?

can cypro + e cause backdoor dht conversion? what to do to prevent that?

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>>32789170
I started injections last week, and I ended up messing up a little on my first go.
I Injected some amount of it with the wrong needle size, and only got around 0.2 (or 0.02 I dont remember the measurments) of the 0.4 I was suppsoed to take, and I got it in my fat instead of my muscle, would this make this part of the dose innefective? or partially innefective atleast, or should it still work?
side question:
what's a good dose for injections

>>32831953
the thought of injection into myself scares me too much, how do you do it and remain chill even after screwing it up

>>32832100
my mama does it so its less bad
18 rn, still live with her

>>32832100
Just don't think about it. Simple as.

>>32831953
>I got it in my fat instead of my muscle.
There is no difference in effectivity between subq and im injections. I prefer subq tho, less painful.
>What's a good dose for injections
Just do your research, you can use one of these calculators to see your estrogen levels to see what dose works best for you. Personally I inject 5mg (0.1 of my vial) of estradiol enathate every week, works great for me and it's pretty popular dose. Get your blood work done too to see your levels (most of the trans ppl do it once every 3-6 months)

Sounds like you diy or you have to because your endo is useless, if that's the case pls do your research to not cause any harm to your body! Good luck

>>32832678
i faint when i get blood testes, no way im injecting e

>>32832100
I always play radical by future on full volume while injecting, helps a lot

>>32832761
Only you can solve your psychological problems.

>>32829736
It's pretty safe. There have been many studies done on it, namely the STAR trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785111/ where women have been tested on it for years.

I'm not sure what you mean by "long term". Please be specific and cite your sources both when asking and answering questions. Anecdotes are one of the worst sources for information.

>>32832851
If they are so scared of injections they prefer dysorphia it's their problem. If you choose good needle size and do it subcutaneously you don't feel anything when injecting, not even a single blood drop (if you do it the right way)

>>32832851
yes well im getting better seeing as ive transitioned into a pin cushion this year. more injections and blood samples than the rest of my life combined
>>32832818
nice song

>>32832915
>scared of injections they prefer dysorphia it's their problem
im on estradiol patch lol

>>32832944
Nice, it's 5 am rn I should go to sleep before I post more dumb shit XD

is there a level simulator or reference for sublingual pills like the injectable one?

>>32789170
is it necessary to take bica after an orchi in case of adrenal spike, even if i was on triptorelin before it? how much bica and for how long?

>>32833306
adrenal as in adrenaline?

>>32833266
Just bullshitting off the top of my head, but I imagine that'd be harder to figure out since people have differing liver functions and responses to the stuff that happens when your E is oral

>>32833352
I don't think so, from what I understand everyone has adrenal glands that also produce low quantities of androgens besides the testes, and apparently it's not uncommon for your body to overcompensate for the loss of your testes by making more androgens with them

>>32833373
hmm how about sublingual/bucal? should be a thing desu ng l

>>32833377
that’s what i was asking for, and those routes also bypass liver. i found this extremely loose table https://transfemscience.org/articles/e2-equivalent-doses/

>>32833374
interesting, i didnt know the adrenal glans did that
https://pubmed.ncbi.nlm.nih.gov/72830/#:~:text=Adrenal%20to%20peripheral%20venous%20testosterone,17-month%20period%20after%20orchiectomy.

https://pubmed.ncbi.nlm.nih.gov/6235240/

https://www.peertechzpublications.com/articles/OJBS-1-101.php#:~:text=Results%3A%20Total%20bilateral%20epididymectomy%20and,morphology%20of%20the%20adrenal%20gland.

old studies but perhaps not?

i didn't have acne for 4 years on hrt like beautiful skin is get compliments on.

i got an orchiectomy and stopped bica. been getting hormonal acne (chin) since. my T is 18ng/dl and my DHT is 12ng/dl. I should prob start bica again, sigh. maybe like 50mg every 5 days

>>32833423
>only tested testosterone, not DHT
>n=10
>rat study
thank you for looking but I know it's happened for some trans girls and getting my DHT tested by the NHS last time was like pulling teeth and took 6 months so I don't want to risk any masculinization. I hope someone can answer my question of how much bica I need to take and for how long

>>32833718
I don't really want to get an orchi if it means the expense of another AA anyway for the rest of my life, since NHS pays for my tripto shots for now. How long ago did you get the orchiectomy?

>>32833759
the adrenal symptoms spiked right after it and have been getting better at least. the orchi was 9 months ago that lab was 6 months ago.

i'm currently just trying saw palmetto twice a day and a higher EV dose for more SHBG. i'd really like to only take one med just EV

>>32833738
one of those studies was n17 no? but still yeah

>>32833820
the 2nd study, showing no increase, it's just 10 unless my brains totally busted (also up at 5am working lol)

>>32833786
ok so like a year to be safe maybe?

>>32833851
word of warning id do like 25mg max but suggest 10-12.5mg bica if you get an orchi. i felt like dog shit on 50mg with an orchi.

50mg every 5 days is what i'd do if i had to do it again. it has a long half life you don't have to split them

i also found out large dose biotin can break you out. so i stopped that 2 days ago to see if that is it. because other than acne i've been fine. so my DHT is prolly fine 9 months post orchi

>>32833905
i have a test late oct to confirm

>>32833871
wait so like do 50 or don't do 50, sorry I'm confused

>>32833935
50mg every 5 days which is effectively 10mg a day due to the half life you don't have to split it

>>32834001
thought so but wasn't sure, thank you. any side effects (like eg cypro prolactinoma stuff) to watch out for?

>>32834018
do blood tests for liver issues

>>32834094
ok will do, thank you

I am 33 and I want to transition, am I still in time to start my treatment?

>>32834114
np gl!

>>32834275
i started at 28 and i'm 32 and happier than i ever was in my 20s. just be realistic and put in the work. and love yourself

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If your body hair (on thighs and arms) stays very dark does that mean I've fucked up (in spite of "correct levels") for past 2 years? And if so does that mean I need to take giga dose injections like 10-20mg EE weekly?

>>32834727
women have some dark leg hair. a massive dose won't fix that. laser will.

what are your E/T/DHT levels?

>>32834847
E2: 550 pg/ml, T: 17 ng/dl and DHT: 12 ng/dl. I'm on 5mg EE/weekly and duta 0.5mg every other day (too poor to afford daily)

>>32826497
bump

>>32835164
but 4mg per week is the MONOtherapy dose. My T is already suppressed by a strong T blocker

>>32835184
what T blocker are you on? can you communicate in full thoughts please

>>32835242
11.25mg of lupron every 3 months and 1.25mg fin everyday. I just don’t mention lupron because most people don’t know anything about it anyway

I’m FtM so this really isn’t my thread, but are there any recs on reputable sources for good 15% minoxidil?

I lost 6kg over 3 days after ffs, which took a lot of fat from my thighs/hips/ass but also from my stomach. Since my e levels are consistently above 100pg/ml when I gain it back will I have less stomach fat?

>>32833374
>it's not uncommon for your body to overcompensate for the loss of your testes by making more androgens with them
ADRENAL GLANDS DON'T "OVERCOMPENSATE" FOR ANYTHING
adrenal steroidogenesis (whole, not just androgens) increases transiently due to surgical stress
please leave honscience on reddit

vitamin e and antiboyotics lolol

>>32828820
22 gauge for drawing

>>32828478
cypro is an antagonist of the androgen receptor which both T and DHT rely on
what's with the anti-cypro FUD in this general?

>>32836088
i might be wrong about the reason why but im not wrong abt the DHT increase am I?

>>32837859
>what's with the anti-cypro FUD in this general?
idk, i see bica shilled over it a lot but ive only heard anecdotes. yeah its non steroidal or whatever but ok? how is that actually better in terms of long term results?

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>>32837859
>what's with the anti-cypro FUD in this general?
where exactly
>cypro is an antagonist of the androgen receptor which both T and DHT rely on
yes but you need very high dosages for that to matter
12.5 mg is suitable for suppressing gonadotropins at best
cypro has a little worse androgen receptor antagonist potency than flutamide, and 750 mg flutamide is equivalent to 50 mg bicalutamide

>>32838042
>12.5 mg is suitable for suppressing gonadotropins at best
gonadotropins control all hormone production in the gonads so that effectively kills off almost all testosterone production

>>32838228
>gonadotropins control all hormone production in the gonads so that effectively kills off almost all testosterone production
but doesn't kill adrenal androgens and DHT overproduction due to faulty enzymes
that's relevant for the few people who are cucked in this regard

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Is it normal to not have much development at 5 months? I'm going to be honest, my consistency hasn't really been that great. Attached is when I've injected and how much I've injected of OTK's Estradiol Cypionate (40mg/ml). It's also mono therapy, but I'm worried since my boobs haven't really grown that much

>>32838320
>dose in ml and not mg

>Is it normal to not have much development at 5 months?
yes

>>32838320
do you get boob pain? i got that pretty early, so if your not feeling like somethings pushing from the inside out then maybe yeah

>>32837685
really? that seems so small. is 18 okay for just one time? it’s all i have to draw with unless i wanna use 25 and i wanted to do my first injection today and not wait till new needles arrive

>>32838354
Yeah I got some boob pain in the beginning, it comes back every once in a while but not as much as in the beginning

>>32838358
maybe you would tell us the concentration and ingredients of your vial instead of letting us guess, it changes things a lot

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I think I got the prolactinoma sisters. Is this bad or does it safe me future domperidone costs?

>>32838418
>Left untreated, a prolactinoma may grow large enough to press on your optic nerve.

>>32838446
Okay so it’s probably fine. Does it stop growing if I stop my cypro

my insurance covers Estrace tablets, is it possible to take them sublingually? theyre made for oral route but id rather sublingual

>>32828580
luteinizing hormone levels cycling can cause drops in oxytocin and physiological responses throughout the body even with no female reproductive organs and independent of dosage-related changes in blood levels of e/prog

>>32839002
source?

>>32839109
some honscience blog that I believed because it cited sources and studies that seemed at least moderately trustworthy and I can find no other explanation for what I observe or experience after telling myself it's just in my head for years and ruling out other possibilities

>>32835851
this is an hrt gen thread, regardless of gender

>>32835984
losing 13lbs in 3 days will largely be water weight stay hydrated and eat when you can

>>32827984
my advice is just do it. in the future they’ll have other ways to make babies from your DNA besides just your sperm and that’s if getting off of HRT doesnt return your sperm anyways

>>32827984
Clomid returns fertility 100% of the time

>>32827984
freeze sperm then you don't have to worry about shit

>>32839151
it makes zero sense. why would LH cycle in women without ovaries? it's persistently elevated since no negative feedback from sex hormones and no effect of rising estradiol levels
admit you just made it up.

>>32839763
why would I make it up? google it and find me a better answer that makes more sense because I want one too

>>32828237
i started breaking out on my face a lot the past couple of months
been on cypro for nearly 5 months
started showering more regularly and washing and changing my bedding more regularly and started to use special chemical cleansers and get into skincare and also doubled my e dose and the spots have started to fade away
my skin is definitely smoother and less oily overall now compared to before HRT, so

how long should you feel the sublingual pill under your tongue? I swear they're lasting like 5 minutes in my mouth and then they just dissappear
should I switch to subbuccal?

>>32840049
it probably didn't even have anything to do with hormones

>>32839847
for fun
the only results i found say oxytocin increases LH

>>32840080
why is androgen receptor sensitivity/androgen metabolism/production altered in women with acne then and why are antiandrogens so effective for acne even when blood tests are OK
the final blow - "Complete Androgen Insensitivity [...] These young girls also present no acne, another sign of the absence of androgen action in target tissues".
"The lack of demonstrable sebum in androgen-insensitive subjects clearly demonstrates the absolute androgen control of sebum production".
acne comes and goes away, but i suspect the androgens still are there. you could just nuke androgens with bicalutamide and no special cleansers and shit would be needed.